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Developed in conjunction with Ext-Joom. In patients that did not respond to lenalidomide treatment, IL-6 was significantly increased. In contrast, lenalidomide, approved for use with multiple myeloma, decreases IL Hee-Sung Kim Novel ghrelin-activated mechanism in the intestines: GLP-1 has a significant role in type-2 diabetes, as it mediates hyperglycemia by inducing insulin production while GLP-2 antagonizes and, therefore, regulates GLP-1 activated insulin-production.
These hormones are commonly modulated by food consumption, implying a interdependence between GLP-1 and GLP-2 which has not been fully investigated.
The research presented here investigated whether there exists a direct relationship between ghrelin and intestinal GLP-1 secretion. The elucidation of this novel pathway, causally linking ghrelin, the glucose transporters, and the glucagon-like peptides, suggests the therapeutic potential of ghrelin-based therapies for type-2 diabetes patients.
Bioinformatics analysis supported this pathway. This model performed similarly to those reported in scientific literature regardless of p53 status, lymph node status, history of endocrine treatment and tumor size.
This indicates that this proposed mechanism has significant implications as a high-potential Bergen research paper project and prognostic target. Daniella Batarseh A Novel Method to Manipulate the Osteoblast Differentiation Process Zeolite is a microporous, aluminosilicate mineral known for its variety of benefits.
The molecule carries a negative charge which attracts positively charged metals, toxins and ions Zeoponix, In this study the osteoblast cells were treated with the chelator, zeolite, in various concentrations ranging from 0. Zeolite proved to induce a dose-dependent increase in cell proliferation.
A potential mechanism for this increase in viability is due to the zeolite s ability to increase DNA synthesis of normal osteoblast cells. The results of this study suggested that proliferation of the cells was notable in the concentrations of 0.
Alkaline phosphatase staining on the cells was also done to show qualitative visual evidence of maturation differentiation. Furthermore, the staining showed quantitative evidence of a decrease in alkaline phosphatase ALP as the concentrations of zeolite increased.
Past literature has stated that the maturation phase, the second phase, of the three-step differentiation process is characterized by maximal expression of ALP PromoCell, Enzyme-linked immunosorbent assays ELISAs were done to determine that the osteoblast cells dedifferentiated when treated with zeolite.
Transmission Electron Microscope and Scanning Electron Microscope were used to establish the incapability of the zeolite to enter the cell and allowed for an elemental analysis of the zeolite, respectively.
The zeolite s structure allows for a high affinity for adsorption, the adhesion of a substance to a surface. Zeolite s framework, composed of a three-dimensional network of AlO4 and SiO4 tetrahedra, is deduced to aid in the adherence of the zeolite to phospholipids.
The composition of zeolite through the elemental evaluation indicates possible mechanisms by which the elements in the particle interact with the cell membrane. The results of this study provide support for zeolite s potential as an effective mitogen and its ability to dedifferentiate osteoblast cells allows for prospective osteoporosis therapy and regeneration.
Dong Bien Kwon The Effect of Catechin on Insulin Sensitivity of Hep G2 Cells Insulin resistance, the physiological condition by which cells do not respond effectively to the insulin hormone, is a primary characteristic of diabetes mellitus type 2.
In many studies, it has been suggested that catechins, a family of flavonoids, may increase insulin sensitivity through an increase in the proteins of the insulin signaling pathway; however, their mechanism of action is not completely understood.
In this study, HepG2 liver carcinoma cells were cultured under diabetic conditions and treated with various concentrations of vitexinO-rhamnoside, a previously uninvestigated flavonoid.
Modulations in the levels of these proteins are indicators of the ability of vitexinO-rhamnoside to mediate insulin sensitivity in HepG2 cells. Dongyeon Kim The Cellular Pathways Mediating the Anti-Tumor Effects of Paeonia suffruticosa on Human Breast Cancer Cells Extracts of Paeonia suffruticosa, traditionally used in herbal medicine to activate blood flow, have also demonstrated anti-tumor, anti-inflammatory and analgesic effects of unknown mechanisms.
The present investigation studied and elucidated potential apoptotic mechanisms of aqueous extract of P.Bergen Community College is a member of the Hispanic Association of Colleges and Universities. The university of Bergen is a research-intensive academic institution that promotes cutting-edge research in a number of disciplines.
Cooperation across disciplines is emphasised. Our students and scientists contribute with knowledge and new insights to meet complex challenges that shape our society.
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Bibliography NoodleBib is a website that will format a bibliography (also called "Works Cited" or "References"). Once you gather your own sources, NoodleBib will input them in the correct format for you - ready to insert into your research paper.
Seacalx AS is a start-up that originates from research at the Insitute of Marine Research (IMR) in Bergen.
The company is based on the invention of Hans Kristian Strand and Torstein Harboe from IMR. Projects from research that have led to licences or sales.
Bergen Teknologioverføring AS. Thormøhlensgate 51; Bergen; Org. no. The Bergen Bullying Research Group (BBRG) is a research team at the University of Bergen in Norway devoted to research on workplace bullying and harassement, destructive leadership, emotions in organisations, and whistleblowing.